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Higher doses tend to cause constipation more often than lower doses

Most clinical benefit emerges over months two through four as doses increase and the body fully adapts to the medication's appetite-suppressing effects

For more on how that works in practice, see our GLP-1 microdosing guide

Retatrutide is a triple GLP-1, GIP, and glucagon receptor agonist currently in Phase 3 clinical trials

The moment a patient hits a dose that causes troublesome nausea or loss of appetite beyond whats manageable, Nooms clinician-designed protocol holds at that dose longer, or even dials back to the prior dose until symptoms subside