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Cardiovascular effects of glucagon-like peptide 1 receptor agonists: From mechanistic studies in humans to clinical outcomes

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Interestingly, a recent proteomics study indicated dynamic changes in islets protein levels of GRK2 in the db/db T2D mice model, with GRK2 being upregulated in hyperglycemic vs euglycemic conditions and GLP-1R displaying an opposite modulation pattern [88, 89]

stratifying by metabolic status, by genetic risk such as GBA and LRRK2 variants in Parkinsons or APOE in Alzheimers, by disease stage, and potentially by GLP-1R polymorphism is the most plausible route to a positive trial

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