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But what happens when you stop taking them

B12 adequacy is directly relevant here since B12 deficiency independently causes cognitive symptoms and mood disturbance, which is another reason the B12-containing formulation is preferred for long-term use

They may need smaller dose increments and more gradual titration to avoid overwhelming their digestive capacity

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Comparing the two requires stitching together separate trials that differ in sponsor, population, duration, and comparator a chain with several weak links