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FIGURE 1 Drug abuse effects on metabolism and epigenetics The metabolic syndrome is a collection of metabolic abnormalities, including hyperinsulinemia, hypertension, dyslipidaemia, and abdominal obesity, and may be triggered by initial discrepancies at the cellular level in critical metabolic pathways

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Kohr G, Eckardt S, Luddens H, Monyer H, Seeburg PH (1994)

Cases of precipitation or worsening of narrow-angle glaucoma and acute eye pain have been reported

Although the mechanisms of action of SCS have not been clearly identified, it is thought to involve both spinal and supraspinal effects and has been shown to be effective for the treatment of various neuropathic pain such as failed back surgery syndrome and complex regional pain syndrome [97-100]