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Among commercially available theophylline-like molecules is Doxofylline (Doxofyl), a newer xanthine derivative with bronchodilator properties similar to theophylline but with fewer side effects

Aberrant activation of PRPS1 has been observed in colorectal cancer 12,13 , hepatocellular carcinoma 14 , breast cancer 15 and T cell acute lymphoblastic leukemia (ALL) 16

For supernatant studies, 40 L of culture media was loaded as previously described (14)

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Furthermore, secondary statistical analyses in the PO+ group demonstrated that none of the above-mentioned differential metabolites remained significant when considering maternal, paternal, or combined parental obesity as separate study groups (Additional file 1: Tables S1S2), thus suggesting that the influence PO could be independent of which progenitor presents obesity