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Cagrilintide and semaglutide work through different mechanisms and have different dosing schedules: Cagrilintide: Amylin receptor agonist Escalation: 0.6 mg 1.2 mg 2.4 mg weekly Three-step titration over 8 weeks Semaglutide: GLP-1 receptor agonist Escalation: 0.25 mg 0.5 mg 1.0 mg 1.7 mg 2.4 mg weekly Five-step titration over 16-20 weeks When combined in CagriSema, both peptides are dosed at 2.4 mg weekly, representing the maximum studied dose for each component

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NEO and BIO were detected using a fluorescence detector with excitation wavelength of 350 nm and emission at 450 nm.The concentrations of the studied metabolites were determined based on the areas of the peaks using external calibration curves

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Results SFN is not toxic to untransformed human T-cells but to jurkat T-leukemia cells To elucidate the influence of SFN on untransformed human T-cells, we prepared freshly isolated peripheral blood T-cells and incubated these cells with SFN