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Subjective craving and event-related brain response to olfactory and visual chocolate cues in binge-eating and healthy individuals

doi: 10.1056/NEJMoa2206286

Appetite usually starts to change within the first week or two, and weight loss tends to follow from around weeks 4 to 8

Because nausea and flushing are the dominant barriers to continuation, the practical reality is that starting exposure and titrating to effect and tolerance, where clinically appropriate, can determine whether a patient stays on therapy at all one of the advantages clinicians cite for adjustable compounded preparations over a single fixed dose

Study Population The present study included 21 children and adolescents suffering from chronic liver disease