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Despite having 50% lower total TG content than WT mice, KO mice showed a general trend of increases in the degree of unsaturation in triglycerides in response to EtOH feeding (Fig

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Although protein-SSG formation occurs by nonenzymatic mechanisms, the de-glutathionylation of proteins is mainly catalyzed by Grxs 32

Once activated by upstream kinases through T172 phosphorylation, AMPK further phosphorylates specific substrates to inhibit lipid and protein synthesis and stimulate glucose uptake, fatty acid oxidation (FAO) and mitochondrial and lysosome biogenesis 6 , collectively maintaining energy and redox homeostasis 7

Glutathione is often called the body's master antioxidant-and for good reason