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Ozempic and Wegovy (both semaglutide) are single GLP-1 receptor agonists, while Zepbound and Mounjaro (both tirzepatide) are dual GLP-1/GIP agonists

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Mfn1 and Mfn2 regulate the fusion of the outer mitochondrial membrane which occurs earlier, whereas OPA1 is normally associated with the fusion of the inner mitochondrial membrane