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Symptoms of acute kidney failure may include: Decreased urine output Swelling in legs, ankles, and feet Fatigue and drowsiness Shortness of breath Itching and joint pain Loss of appetite and nausea Confusion and seizures (in severe cases) Acute kidney failure can be caused by factors that affect blood flow to the kidneys, block urine from leaving the kidneys, or directly damage the kidneys

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10.12932/AP-270217-0035 162 WuE

Several critical questions remain unresolved: (1) most existing studies are confined to animal and cellular models, with a notable lack of large-scale population-based investigations and clinical validation, thereby impeding translational application