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It has been shown that cysteine deprivation and treatment with erastin induce ferroptosis and subsequently lead to orbital fibroblast proliferation (348)

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Restoring active glutathione (GSH) levels and the ratio of active reduce to inactive oxidized GSH/GSSG can correct some, if not all, of the energy depletion

doi: 10.1158/0008-5472.CAN-10-3323 276 WuQLiJLiZSunSZhuSWangLet al

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