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The reviews analysis confirms that synthetic GLP-1 medications like semaglutide and tirzepatide, originally developed to control blood sugar, offer clinically validated protection against cardiovascular disease (CVD), chronic kidney disease (CKD), and metabolic dysfunction-associated steatotic liver disease (MASLD)-related outcomes, including improvements in steatosis and fibrosis-related endpoints

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Li CJ, Yu Q, Yu P, Yu TL, Zhang QM, Lu S, et al

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Neural dysfunction and metabolic imbalances in diabetic rats