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Recent research has demonstrated that YAP/TAZ potentially facilitates the resistance of hepatocellular carcinoma cells to sorafenib-induced ferroptosis through the co-regulation of SLC7A11 expression with ATF4

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Am J Clin Nutr 86: 1738-1744 Malaguarnera M, Vacante M, Avitabile T, Malaguarnera M, Cammalleri L, et al

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This usually includes evidence of a BMI above 27 with comorbidities (hypertension, diabetes, sleep apnea) or BMI above 30, plus documentation of failed prior weight loss interventions