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Here, starting from the intrinsic hallmarks of cancer and cell death, we discuss the theoretical basis of cell death induction as a cancer treatment

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Because it promotes detoxification and alters cellular signaling, some individuals may experience a temporary exacerbation of symptomsoften colloquially referred to as a 'Herxheimer reaction' or detox flareas toxins are mobilized for excretion

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Concerns have been raised about long-term berberine use and kidney health