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Different agonists tip this balance differently, favoring G protein signaling or arrestin recruitment to varying degrees, a phenomenon called biased agonism

The body thinks it has enough hormone

This mechanism not only maintains the stemness of GC stem cells, but also enhances their resistance to ferroptosis

ABSTRACT: Since the approval of the first dipeptidyl peptidase-4 (DPP-4) inhibitor in the United States in 2006, the use of these agents as second-line oral antihyperglycemic therapy in type 2 diabetes management has been established