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The answer, based on recent randomized controlled trial data, is that the skeletal cost of GLP-1 therapy deserves serious attention

Sources Gender Differences in GH Response to Exercise Felsing NE, et al

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In the SURMOUNT-1 trial, which included adults with obesity or overweight (without diabetes), participants achieved remarkable average weight loss over 72 weeks: At the 5 mg dose: Participants lost an average of 16% of their starting body weight

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