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doi: 10.1016/j.ijantimicag.2009.10.009 179 KimGK

BMI 30.0 kg m 2 or 27.0 kg m 2 with the presence of at least one of the following weight-related comorbidities (treated or untreated): hypertension, dyslipidemia, obstructive sleep apnea or cardiovascular disease

Temporary fatigue or drowsiness following higher doses

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(Genome Medicine, March 2026) with 1,119 participants, non-carriers hit HbA1c targets at 25 percent, p.S539W carriers at 11.5 percent, and p.D563G at 18.5 percent