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In rare cases where B12 is essential but acne remains intractable, dermatologists may consider oral isotretinoin, which in the UK can only be initiated by consultant dermatologists and requires strict monitoring, including a pregnancy prevention programme for women of childbearing potential

Reported side effects in humans Clinical experience and user reports suggest that side effects, when they occur, are generally mild

Moreover, we believe that employers (that offer or sponsor employee health plans), researchers, policy officials, and similar members of the public could utilize this data to promote competition and choice, ultimately helping to improve healthcare value

Some patients report mild diarrhoea, nausea, or headache following administration, though these symptoms are usually transient

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