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Hormones play an important role in metabolism, appetite regulation, energy production, sleep quality, and body composition

Anyone monitoring for retatrutide-related hair loss should understand that this typically relates to rapid weight loss rather than direct drug toxicity, and it generally resolves as weight stabilizes

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By contrast, pair-feeding causes less-pronounced weight loss, while weight matching requires a 51% decrease in food intake

Science 291 (5504): 643-6