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Dosing and Pharmacokinetic Study To explore the mechanism of low bioavailability of ASD, ASD was intragastrically administrated with vegetable oil to improve solubility, pretreated metronidazole to inhibit intestinal flora, verapamil to inhibit P-glycoprotein (P-gp) and with urea to enhance intestinal penetration ( n = 5 per group) and fasted for 12 h before test drug administration

DHEA, dehydroepiandrosterone

Common biomarkers that inform treatment decision-making include oxidized glutathione (GSSG), total antioxidant capacity (TAC), and malondialdehyde (MDA) levels

The condition also carries psychological burden, with higher rates of anxiety, depression, and reduced quality of life

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