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Concurrently, the nanoreactors also activate the systemic immune system in mice, preventing tumor metastasis and recurrence

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One of the major unresolved issues is the temporal and mechanistic hierarchy of organelle dysfunction in AP, particularly the relative sequence linking Ca 2+ overload, mitochondrial depolarization, bioenergetic failure, oxidative stress, defective mitophagy, inflammasome activation, and necrotic cell death

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