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This typically takes 3-9 months

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IVA, isovaleric acidemia

In this setting, harmonisation and batch-aware mapping are prerequisites, and integration frequently refers to aligning representations across datasets so that cell-state programs and pathway signals are reproducible [89, 451]

Patients have found strategies to manage these side effects, such as adjusting meal sizes, timing of medication administration, and gradual dose escalation, which have helped in minimizing discomfort and improving adherence to the treatment