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Large-scale human investigations, including cross-sectional and longitudinal analyses, 7 revealed that elevated GABA levels and reduced CBF in the PFC were associated with more severe symptoms and poorer recovery trajectories (Study 1)

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Additional studies often assess compound stability in solution and consistency across in vitro systems to support reliable and reproducible experimental outcomes

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It acts as a selective antagonist of the sigma-1 receptor, a protein involved in various cellular processes, including neurotransmission and cell survival