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The terminal half-life was determined based on the terminal slope, which was obtained by converting the micro-constants from the 2-compartment model to macro constants (Talevi and Bellera, 2021) The area under the concentration-time curve from 0 to 3 h (AUC 03hr ) was obtained by integrating the curve over this time period, while the total AUC (AUC 0- ) was derived using the dose divided by clearance