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Trial REDEFINE 2 Phase 3 Duration 68 weeks Population (N) 1,206 adults with T2D + obesity/overweight Key Result 13.7% mean weight change vs 3.4% placebo (treatment-policy)

Doing so does not increase their effectiveness and may increase the risk of severe side effects

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For example, a retrospective cohort study of prediabetic patients (Hemoglobin A1c 5.7%6.4%, no use of antidiabetic drugs, and no prior diagnosis of type 2 diabetes mellitus (T2DM)) indicated that prediabetes is associated with an increased risk of PD, with a hazard ratio of 1.07 (95% confidence interval: 1.001.14) [19]