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Table 1 Therapeutic strategies targeting ECM remodeling and related pathways in MAFLD

Contact your GP if you experience : Persistent low mood, loss of interest in activities, or feelings of hopelessness lasting more than two weeks Significant anxiety, panic attacks, or intrusive thoughts Changes in sleep patterns, appetite (beyond expected effects), or energy levels Thoughts of self-harm or suicide ( call 999 or attend A&E if you are in immediate danger

2 The viscous gel formed by glucomannan slows the digestion and absorption of carbohydrates, which stabilizes blood glucose levels, particularly for individuals with insulin resistance or type 2 diabetes

NHS behaviour-change teams often counsel that rapid early loss followed by slower, steadier progress is success, not failure

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