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doi: 10.1371/journal.pone.0208906 126 LeeuwendaalNKHayesJJStantonCOToolePWBeresfordTP
Under normal physiological conditions, NRF2 acts as a master regulator of antioxidant response, becoming activated during oxidative stress to upregulate antioxidant gene expression [9]
Important caveat: the foundational 2014 mechanism paper was formally retracted in April 2025 due to falsified data no approved human clinical trials exist
[DOI] [PMC free article] [PubMed] [Google Scholar] 29.Laurberg P., Pedersen K.M., Vestergaard H., Sigurdsson G
For martial artists, this often means prioritizing 8 to 9 hours of sleep opportunity during injury recovery, maintaining consistent sleep schedules even when not training, creating dark and cool sleeping environments, and limiting late-evening training that may disrupt sleep onset
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