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Patients should be counseled to contact their healthcare provider if they experience any of the following: Severe or persistent gastrointestinal symptoms including intractable nausea or vomiting lasting more than 24-48 hours, inability to maintain adequate oral hydration, severe abdominal pain (particularly if localized to the upper abdomen or radiating to the back), or signs of gastrointestinal bleeding such as bloody or black stools

27 Additionally, this class of drugs can cause hypertension and, rarely, malignant hypertension

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For the weight management indication, the general requirement is a BMI of 30 or above, or 27 or above with at least one weight-related comorbidity