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J Hum Nutr Diet : Official J British Dietetic Assoc

For gene expression analysis, cDNA was synthesized using the First Strand cDNA-Synthesis Kit with Random Hexamer Primers (K1612, Thermo Fisher Scientific) according to manufacturers instructions

The Lancet 375, 9981006 (2010)

ST1326 belongs to formyl-carnitine derivatives, which has a specific and reversible inhibitory effect on liver CPT1A, and is currently used as a novel anti-hyperglycemic drug ( It was discovered that C75 directly stimulated CPT1A activity (Idrovo et al., 2012)

Patients with established cardiovascular disease should receive a pharmacological treatment intensification with an agent that has demonstrated benefit in cardiovascular safety studies: In patients with pre-existing atherosclerotic cardiovascular disease (ASCVD), a GLP-1 receptor agonist, or SGLT-2 inhibitor with characterized cardiovascular safety should be used