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10.1007/s12035-014-8838-y 134 YangH.LundbckP.OttossonL.Erlandsson-HarrisH.VenereauE.BianchiM

However, PKC plays an integral role in modulating the actions of proinflammatory mediators by phosphorylating cytosolic PLA2 (cPLA2) and inducing the formation of arachidonic acid through phospholipids, which in response leads to the formation of functional eicosanoids in stimulated cells [146]

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In addition, other antioxidant systemsincluding GSH, thioredoxin (Trx), and peroxiredoxinsare highly active in CRC cells and collectively reinforce their defense against oxidative stress [34, 37, 38]

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