BMC Bioinformatics 10: 162
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While no significant changes were observed in free testosterone or SHBG levels, treatment with GLP-1 RAs was associated with a significant rise in bioavailable testosterone and a notable reduction in HbA1c, indicating potential dual metabolic and endocrine benefits
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This provides a genuine biological mechanism for what people describe anecdotally as mental quiet GLP-1 isnt only reducing hunger signals originating from the gut, it appears to also be dampening the brains tendency to generate food-related thoughts specifically during unfocused, idle moments, which lines up closely with how people describe food noise actually showing up in daily life: not at mealtimes, but in the in-between moments