Leah Joseph, MD, FACP , youll receive a personalized treatment plan designed to optimize your health and wellness
97,98 These results underscore the need for further investigation of the interplay between FXR and TGR5, particularly in the context of GLP-1RAs treatment, to better understand the mechanisms underlying biliary and metabolic complications and to guide patient management strategies
Sphingolipids, which can be divided into three different structural categories, i.e., sphingoid bases and derivatives, ceramides, and complex sphingolipids ( In this review, we will mainly discuss [i] the alterations in sphingolipid metabolism possibly involved in MASLD pathogenesis, with particular emphasis on those related to its progression to MASH, and [ii] the impact of current and potentially novel therapies that target sphingolipid metabolism for MASH treatment
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Progress will hinge on methods that read out metabolism and structure together
