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Early clinical trial data, most notably from the Phase 2 trial published in the New England Journal of Medicine (Jastreboff et al., 2023), demonstrated that retatrutide produced substantial reductions in body weight up to approximately 24% over 48 weeks at the highest doses studied

Potential mechanisms underlying clinical benefits of GLP-1RAs GLP-1 receptors are thought to be expressed on atrial and ventricular cardiomyocytes, endothelial cells in the human heart, and endothelial and smooth muscle cells in blood vessels [21]

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