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If the liver is sluggish and cannot detoxify properly, our bowels, energy levels, and overall health are affected

Additionally, the issues of weight regain and altered metabolic outcomes following drug discontinuation emphasize the importance of long-term studies investigating the impacts of the hormonal and CNS on weight regain to optimize safety and efficacy [119,120]

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To ensure the achievement of a 1000-kcal deficit and similar weight loss, participants were housed in a metabolic ward during the treatment period (13)