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Estimated prevalence of Barretts in the general population is 5%, and the majority have do not have dysplasia, but if there is high grade dysplasia, there is a 7% annual risk of developing adenocarcinoma, which is what we ultimately want to prevent

doi: 10.1073/pnas.1906722116 29 MeskauskieneR.NaterM.GoslingsD.KesslerF.op den CampR.ApelK

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In apoE / mice, AMPK activation enhanced expression of ABCA1 and ABCG1 in peritoneal macrophages without affecting LXR expression, while increasing SR-B1 expression in the liver [12]