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B12 deficiency is associated with depression, cognitive impairment, irritability, and in severe cases, psychosis

but why is this observation not consistent across the studies

Symptoms that may indicate low Vitamin B levels include fatigue, depression, low blood pressure, constipation, memory loss, weakness, sore tongue, tingling and numbness in fingers and toes, mood changes and difficulty walking

This is especially important for women, vegetarians, people with PMOS, postpartum patients, those with heavy menstrual bleeding, and patients with a history of bariatric surgery or low iron stores

This variability in study quality could impact the reliability and strength of conclusions drawn from the collective evidence