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Begin at 1 mg daily for the first 1-2 weeks to assess tolerance, then increase to 1.5-2 mg daily if well-tolerated

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Interestingly, based on study evidence, sex differences also critically modulate oxidative stress responses and neurodegeneration susceptibility through distinct molecular mechanisms: Females exhibit superior antioxidant capacity via estrogenmediated Nrf2 activation, enhancing GSH synthesis and ROS clearance, while males demonstrate heightened vulnerability to oxidative DNA/lipid damage (e.g., elevated 8oxoG) due to androgendriven mitochondrial ROS overproduction [155]