More commonly reported minor side effects include GI disturbances such as abdominal cramping, nausea, flatulence, loose stools, and alterations in taste perception (543, 559)
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For the long-term management of pernicious anemia after B12 replenishment, parenteral treatment with B12 every 13 months seems sufficient to prevent a relapse [13,14,15]
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This is especially meaningful for chronic kidney disease, where inflammation, immune dysfunction, and tissue damage drive long-term decline