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Bone-marrow derived macrophage generation 812 week old C57BL/6J mice (weighing approximately 2025 g) were euthanized by gradual-fill CO 2 inhalation (2030% chamber volume per minute) without prior anesthesia, in accordance with the HPRA, Ireland, Directive 2010/63/EU of the European Parliament, the ARRIVE guidelines, and the Guide for the Care and Use of Laboratory Animals

Major factors include interleukin-17 (IL-17), interleukin-23 (IL-23), T-cells, dendritic cells, tumor necrosis factor alpha (TNF-) and pro-inflammatory cytokines [11]

D.et al (2025)

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Because the Kras G12D -Myc axis has been suggested to induce Nrf2 gene expression and increased the activity of Nrf2 in pancreatic cancers (DeNicola et al., 2011), the activation of the non-oxidative arm of the pentose phosphate pathway might depend on Nrf2