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Nat Immunol (2021) 22(9):110717

If you encounter Canadian or cross-border offers for compounded GLP-1s, treat them with significant caution

You should not take semaglutide or tirzepatide if you have: Personal or family history of medullary thyroid carcinoma Multiple endocrine neoplasia syndrome type 2 (MEN2) History of pancreatitis or gallbladder disease Severe kidney or liver disease Diabetic retinopathy (in some cases) Severe gastrointestinal disease Pregnancy or breastfeeding This is not a complete list of contraindications

Glutamine: Eects on the immune system, protein metabolism and intestinal function