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Markers of immune activation: Novel biomarkers to predict the early-warning indicator of patients with papillary thyroid carcinoma

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Future studies combining -cell states defined by scRNA-seq and snATAC-seq with quantitative measures of SCFA, indole derivatives, or endotoxemia have the potential to reveal whether specific -cell subpopulations preferentially associate with distinct microbiota-derived signatures or display differential transcriptional responses to incretin- and SCFA-dependent interventions, thereby advancing a systems-level understanding of microbiota-cell interactions

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Future advancements must focus on improving technical methodologies, including the extraction and identification technologies of TCM