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These all severely affect endothelium function

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Providing the closely interrelated increased pressure in the three body cavities interacting with each other rapidly transmitted through the venous system [28,29] (and thereby, venous system as therapy target [20,21,22,23,24,25,26,27]), the occluded superior sagittal sinus in addition to the brain swelling and lesions and increased pressure in the superior sagittal sinus may induce a comparable deadly syndrome

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Rare adverse reactions may include allergic reactions like skin rash, hives, itching, or swelling of the face