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Tirzepatide acts on two targets in the body, leading to greater initial weight loss, which also may translate to regaining more weight after switching to orforglipron

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Lower doses may be reasonable for some patients, but microdosing is still off-label, and the strongest evidence still comes from standard therapeutic dosing in populations with clinical obesity or metabolic disease, and many of the broader claims around low-dose use exceed what the evidence supports

2.4 In vitro cell culture Caco-2 cells (passage #51) were cultured in DMEM (supplemented with 10% FBS) for 3 days on plastic coverslips at the bottom of 1 mL wells in 24-well cluster plates at a density of 1 10 6 cells/mL

Testing visit number was included in all models as a covariate to account for the practice effect