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A greater proportion of PDAC-associated diabetes in NOD individuals occur within 0 to 12, 12 to 24, and 24 to 36 months prior to PDAC diagnosis, while similar proportions of PDAC-associated diabetes and control populations occur past 36 months, thus establishing the criticality of diabetes presentation 3 years before PDAC as a window of opportunity for early detection ( Figure 4A ) (91)

The effect of preoperative melatonin on nuclear erythroid 2-related factor 2 activation in patients undergoing coronary artery bypass grafting surgery

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