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T2DM and hyperglycemia are also associated with oxidative stress from the overproduction of reactive oxygen species (ROS) and decreased efficiency of scavengers systems ( Furthermore, our lab has previously shown that individuals with T2DM have lowered levels of GSH due to decreased levels of both GCL and GSS protein compared to healthy subjects ( M

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They suggested that rapid correction of high blood sugar might explain some of what they saw

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We suggest that these different types of redundancy help ensure that this balance is maintained, even in varied environmental conditions, such as different temperatures, access to food/nutrition, crowding, etc