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The underlying tissue in these wounds appeared dark red or mottled by day 7, which was identified as granulation tissue

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Initial results from early randomized placebo-controlled studies such as the Women's Health Initiative suggesting that HRT increased the risk of coronary heart disease and breast cancer across the board in postmenopausal women were inappropriately interpreted and communicated with the public, leading to sharp declines in HRT prescriptions (115, 116)