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In contrast, the bulkier Y37 rAmy in rAmy-bound AMY 2 R prevents equivalent interactions of N35 rAmy with RAMP2, and instead the bulkier Y37 rAmy forms interactions with E101 RAMP2 and F111 RAMP2 stabilising the peptide at the CTR/RAMP ECD interface in the bypass conformation

It allows the recruitment of other immune cells to improve anti-infective efficiency

Future studies are required to evaluate the efficacy of this method in preventing shrimp-induced anaphylaxis in animal models and eventually in human clinical trials [144, 145]

Developmental and Comparative Immunology

Targeted immunomodulators Targeted therapies exert therapeutic effects on AR by specifically modulating key molecules or cytokines in the immune response pathway