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One trial included healthy non-obese participants, demonstrating that the favorable safety profile was not unique to obese individuals
Over-interpretation of secondary outcomes may lead to spurious inferences, underscoring the need for caution when translating these findings into clinical reassurance.This aligns with emerging data linking metabolic improvements such as weight loss, insulin sensitivity, and reduced inflammation to decreased malignancy risk in high-risk populations with type 2 diabetes or obesity (Marso et al., 2016a
The Lancet 390 (10093), 521530