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Because MOTS-c enhances insulin-independent glucose uptake, patients with type 1 diabetes or those using exogenous insulin should be monitored carefully to prevent hypoglycemia, though this theoretical risk has not materialized in clinical reports to date

Curcumin inhibits the AKT/NF-B signaling via CpG demethylation of the promoter and restoration of NEP in the N2a cell line

Ketodiets and Nutraceuticals Expert Panels: KetoNut, Italian Society of Nutraceuticals (SINut) and the Italian Association of Dietetics and Clinical Nutrition (ADI)

If a small number of pathways are consistently dysregulated across these conditions, targeting these pathways could potentially provide symptom relief for a broad spectrum of patients with different diagnoses

Negative response, meaning visible worsening or persistent adverse effects, warrants discontinuation and reassessment