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To maintain oxidation equilibrium, HIF-1 activation under hypoxia suppresses mitochondrial respiration by inhibiting oxygen consumption and fatty acid oxidation via HIG2-mediated suppression of lipolysis

10.1007/s00401-019-02040-w Acta Neuropathol

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In other cases, the aetiology is not known, like for example in idiopathic pulmonary fibrosis (60), affecting mainly the elderly, or in systemic sclerosis, which presents with an autoimmune component and affects the skin as well as internal organs (61, 62)

2-4 weeks Skin feels smoother and better hydrated 4-8 weeks Firmness and tone start to look more even 3+ months Deeper, more lasting changes as collagen rebuilds Administration If your skin gets irritated, red, itchy, or flaky, stop using the cream and let your provider know